Having lost at home just three times all season, Darren Way’s side will be in buoyant mood coming into the West Country clash.
Fresh from picking up a point at play-off chasing Mansfield last weekend, Town will be looking to build on their last outing on home soil which saw Port Vale dispatched in the Emirates FA Cup second round replay.
Otis Khan scored twice to become Yeovil’s outright top scorer with nine goals, whilst Francois Zoko tucked home the winner with his eighth of the season.
The Green and Whites are without any fresh injury concerns, with Rhys Browne (hamstring) and Oscar Gobern (hamstring) the only absentees.
With virtually a full squad to pick from, the Glovers will lineup against an Exeter side unbeaten in their last two outings.
FA Cup progression against Forest Green Rovers was backed up with a league win over Stevenage, a result which sees Paul Tisdale’s side come to Somerset inside the automatic promotion spots.
Looking to go one better than last season’s play-off final disappointment, the Grecians head to Huish boasting top scorers Jayden Stockley (11 goals) and former Town striker Reuben Reid (eight goals).
Saturday’s fixture will be the 15 competitive meeting between the two sides.
Drawing five and winning four, Yeovil will be looking to match City’s five victories.
Town’s last win at home to Exeter came in 2010, with Stefan Stam and Ryan Mason securing a 2-1 win.
Lee Swabey (Devon) will take charge of the Sky Bet League Two clash.
Saturday will be Mr Swabey’s sixth match of the season, having last overseen Luton’s 2-1 win at Forest Green Rovers last weekend, issuing one red and four yellow cards.
Ravel Cheosiaua (Worcestershire) and Andrew Williams (Middlesex) will be his assistants, with Mark Pottage (Dorset) acting as fourth official.
Darren Way and Jake Gray’s pre-match thoughts can be viewed on iFollow Glovers.
On matchday, minute-by-minute updates will be provided on YTFC’s official Twitter account and live matchday centre.
If you’re unable to attend the game, live audio commentary is available via the iFollow Glovers service, with the monthly and season subscriptions offering full-match replays from Sunday.
A full match report will follow on YTFC.net at full time with post-match reaction from the manager and a member of the playing staff following soon after.
Tickets for the match are available to buy in advance and on the day. For more information, visit our Home Tickets section.