There was no match action last weekend as Sessi D’Almeida, Rhys Browne and Enes Mahmutovic all completed international duty.
Town’s last taste of match action came in the defeat to Stockport County in the first round of the Emirates FA Cup, prior to a 10-day period without a fixture.
Alex Fisher was on target that day but later went off injured along with fellow striker Olufela Olomola.
The attacking duo will be unavailable for Saturday’s trip along with Omar Sowumni, Jordan Green, James Bailey and Diallang Jaiyesimi although Gary Warren is likely to return to the matchday 18.
In their last league outing, the Glovers somehow lost to Morecambe despite a dominant display to suffer a first league defeat in five matches.
Travelling to Cheshire, the green and whites will take on a Macclesfield side who currently lie bottom of the table on seven points.
They parted company with manager Mark Yates last month and claimed their first league win of the season shortly after but have lost their last four league matches under bosses Danny Whitaker and Neil Howarth.
Saturday’s clash between the two sides will be the first since 2005.
The green and whites ran out 4-0 winners at Huish Park in an FA Cup first round replay seeing.
Darren Way and Paul Terry were amongst the scorers that day as Lee Johnson and Arron Davies completed the rout.
That fixture is the only win in six matches against the Silkmen who themselves have claimed victory on three occasions with two draws.
Paul Marsden will be the man with the whistle in Chesire at the weekend.
Marsden will be taking charge of his first Yeovil Town match on Saturday but has refereed Macclesfield on two occasions, this season’s 1-1 draw with Cheltenham and last season’s 2-2 draw with Ebbsfleet sending off Nathan Blissett for the Silkmen.
He will be assisted by Matthew Jones and Steven Rushton with Marvyn Amphlett as the fourth official.
The pre-match thoughts of Gary Warren and manager Darren Way can be viewed on iFollow Glovers.
On matchday, minute-by-minute updates will be provided on YTFC’s official Twitter account and live matchday centre.
If you’re unable to attend the game, overseas supporters can watch the game live via the iFollow Glovers service!
A full match report will follow on YTFC.net at full time with post-match reaction from the manager and a member of the playing staff following soon after.