Shaun Derry’s side head to Somerset in Sky Bet League Two looking for a first win in five, whilst the Green & Whites are looking to record back-to-back league wins.
Lewis Wing, Rhys Browne and Jake Gray secured a 3-0 win over Grimsby Town in midweek, with United going down 3-1 at Coventry City.
Having hosted Chesterfield, Manchester United and Grimsby in succession at Huish Park, Darren Way’s side will continue to try and make home advantage count at the weekend.
They’ll do so with no fresh injury concerns, although will still be without the services of Bevis Mugabi (hamstring), Oscar Gobern (hamstring), Marcus Barnes (ankle), James Bailey (knee) and Dan Alfei (knee).
Joint top scorer Otis Khan will serve the third of a five-match suspension, leaving Town with 19 players to choose from.
The Cambridgeshire outfit will head south hoping top scorer Uche Ikpeazu can be the difference (10 goals), having netted in the reverse fixture.
Yeovil go into the encounter with five victories to Cambridge’s four in the previous 10 meetings.
However, the Glovers are without a win in the last five encounters, narrowly losing the reverse fixture 2-1 back in October despite Bevis Mugabi’s headed effort.
Town’s most emphatic win at Huish Park came in 2004, as Gavin Williams, Andy Bishop, Adam Stansfield and Colin Miles secured a 4-1 win.
Darren Drysdale (Lincolnshire) will be the man in the middle on Saturday.
Taking charge of his 32nd match of the season, it will be his first involving Town since March 2017 having overseen the 3-3 draw at Exeter City.
Mr Drysdale will be assisted by Adrian Tranter (Dorset) and Kevin Howick (Oxfordshire) with Louis Marks (Hampshire) acting as fourth official.
The pre-match thoughts of manager Darren Way and Rhys Browne can be viewed on iFollow Glovers.
If you’re unable to attend the game, live audio commentary is available via the iFollow Glovers service, with the monthly and season subscriptions offering full-match replays from Sunday.
A full match report will follow on YTFC.net at full time with post-match reaction from the manager and a member of the playing staff following soon after.
Home and away supporters can buy tickets on the day of the match. Buy in advance to save money and beat matchday queues at Huish Park.
For more information, visit our Home Tickets page.