The Glovers welcome the O’s to Somerset off the back of picking up four points from their last two Sky Bet League Two games.
Darren Way’s side recorded their first league win of 2017 with a 2-1 home victory over promotion contenders Plymouth Argyle before earning a point away at Hartlepool United.
Orient are winless in seven – losing six in a row – a sequence which has seen them slip into the bottom two.
The London outfit have won their previous two matches at Huish Park but suffered a 4-0 defeat to Town in the third round of the Emirates FA Cup in 2014.
Last time out, Yeovil left Brisbane Road with all three points when Tom Eaves rose highest to nod home Matt Butcher’s cross.
Supporters can buy tickets for the game in person at the ticket office, online or by phone on 01935 847888.
Tickets are available on the day but at a £2 price increase*.