The winger’s strike put Town into a commanding 2-0 lead after just 17 minutes in Lancashire, only for the Shrimps to comeback and snatch a dramatic 4-3 win.
Producing a positive run from midway inside the Morecambe half into the box, the 22-year-old exchanged a quick one-two with Jake Gray before curling a pinpoint effort up and over Barry Roche.
His 10th goal of the season, Khan became the first Yeovil player since Phil Jevons in 2004 to score 10 goals before the turn of the year.
The winners of the Sky Bet EFL Goals of the Month are chosen by a fan poll on skysports.com.
The shortlist for the poll is decided by a judging panel following suggestions from supporters via Twitter.
The judging panel comprises Sky Sports’ EFL expert Don Goodman; Sky Bet Sponsorship Executive Michael Holinski and EFL Senior Media Manager Rob Meaden.
To suggest a goal to be considered for future Sky Bet Goal of the Month awards, fans can tweet details of their nominated goal to @SkyBet using #SkyBetGotM.
The full Sky Bet League Two nominations are as follows:
Jamal Campbell-Ryce – BARNET v Morecambe – 16th December
There seemed no danger when Campbell-Ryce got the ball near the touchline on halfway. That was until he jinked inside, strode forward and curled home a sumptuous 30-yarder.
Callum Ainley – CREWE ALEXANDRA v Crawley Town – 16th December
Collecting a raking pass near the by-line, the 20-year-old jinked inside a defender and left Crawley keeper Glenn Morris motionless with an arrowhead shot into the far top corner.
Otis Khan – Morecambe v YEOVIL TOWN – 29th December
Shielding the ball as drove towards the area, Khan exchanged passes with teammate Jake Gray, took one touch and then looped his unstoppable shot into the far corner.