Sitting at the top of Sky Bet League Two, John Coleman’s side need a victory to ensure their automatic promotion after Exeter held them to a 1-1 draw on Saturday.
Conversely, a Yeovil win coupled with a Chesterfield loss at Exeter will confirm Sky Bet League Two status for another season with four games remaining.
Town have become accustomed to frustrating the division’s play-off hopefuls in the last six matches, picking up wins against Colchester and Coventry as well as draws with Exeter and Swindon.
Looking to do the same again, Darren Way’s side head to Lancashire looking to keep Stanley’s champagne on ice for a second successive match.
After suffering a narrow defeat at home to high-flying Wycombe on Saturday, the Green & Whites will be aiming to stretch their unbeaten run on the road to five matches.
The Glovers are unlikely to be boosted by the return of Sam Surridge (hamstring), with Artur Krysiak, James Bailey, Dan Alfei (all knee) and Jake Gray (ankle) remaining sidelined. Nathan Smith has returned to training but the trip may come too soon.
Striving to get Accrington over the line, striker Billy Kee (22 goals) will provide the likeliest threat with Kayden Jackson boasting a healthy 14 goals.
Town will be looking to add to their three wins and three draws from the seven previous encounters.
However, Yeovil are yet to pick up a victory at the Wham Stadium boasting two draws and a loss, one of which in the Emirates FA Cup.
Last season in the same fixture, Rommy Boco’s 90th minute equaliser cancelled out Otis Khan’s free-kick.
Stephen Martin (Staffordshire) will be the man in the middle on Tuesday night.
Taking charge of predominantly Championship matches this season, Mr Martin will officiate his first match involving the Glovers since the 2-2 draw at Barnet in March last season.
He’ll be assisted by Jonathan Hunt (Merseyside) and David Avent (Northamptonshire) with Robert Jones (Merseyside) acting as fourth official.
If you’re unable to attend the game, live audio commentary is available via the iFollow Glovers service, with the monthly and season subscriptions offering full-match replays from Sunday.
A full match report will follow on YTFC.net at full time with post-match reaction from the manager and a member of the playing staff following soon after.