Fellow strike Sam Surridge grabbed his first Glovers strike at St James Park and Rhys Browne was also on target in the victory.
Darren Way has no new injury concerns ahead of the tie and has already stated his intent to do well in the competition.
Chelsea’s youngsters have never won a match in the tournament since entering it in the summer of 2016.
Their previous fixture at Plymouth Argyle ended 2-2 with Callum Hudson-Odoi scoring twice as the young Blues squandered a two-goal lead and lost on penalties.
Joe Edwards’ side have a host of young talent and will provide a different tactical test for Yeovil.
Chelsea Under-21s are currently in the bottom two in the Premier League 2 and will hope the Checkatrade Trophy provides a healthy distraction from their indifferent league campaign.
The two sides have never faced each other.
Chelsea were knocked out in the group stage last season, while Yeovil reached the quarter-finals.
Kevin Johnson will be the man in the middle this weekend.
The Somerset-born official has refereed 12 games this season – mostly in League Two.
He has issued 43 yellow cards and six reds – three of which came in one game.
Johnson officiated Town’s home win over Plymouth Argyle last season and the victory against Portsmouth in the Checkatrade Trophy.
He will be assisted by Matt Eva (Surrey) and Justin Amey (Dorset) with Brett Huxtable (Devon) acting as fourth official.
On matchday, minute-by-minute updates will be provided on YTFC’s official Twitter account and live matchday centre.
If you’re unable to attend the game, live audio commentary is available via the iFollow Glovers service, with the monthly and season subscriptions offering full-match replays from Sunday.
A full match report will follow on YTFC.net at full-time with post-match reaction from the manager and a member of the playing staff following soon after.
Junior tickets are FREE while adults are priced at £10. Seniors and young persons are available at £5. Fans can purchase from the ticket office this evening.