The quartet of Shaun Donnellan, Rhys Browne, Sessi D'Almeida and Enes Mahmutovic will all leave Huish Park to represent their respecitve countries.
Donnellan, a Republic of Ireland Under-21 regular, will continue to help Eire look to qualify for the UEFA Under-21 European Championship in their qualifiers against Israel and Germany on Thursday 11th and Tuesday 16th respectively.
Returning to fitness last month after missing the start of the 2018/19 campaign, Browne has been called-up for Antigua & Barbuda's CONCACAF Nation's League qualifier in the Bahamas on Friday 12th, before returning to Somerset.
After receiving a first call-up since 2015 last month, D'Almeida has been included in the Benin squad to take on Algeria home and away in the AFCON qualification stage, taking place on Friday 12th and Tuesday 16th.
Completing the quartet, Middlesbrough loanee Mahmutovic will continue his UEFA Nations League campaign with Luxembourg against Belarus and San Marino on Friday 12th and Monday 15th.
As a result of Yeovil's absentees, Saturday's Sky Bet League Two fixture away to Cheltenham Town has been postponed with the fixture yet to be rearranged.
Republic of Ireland Under-21s
Israel v Republic of Ireland U21s - Thursday, 11th October (1500)
Germany v Republic of Ireland U21s - Tuesday, 16th October (1715)
Antigua & Barbuda
Bahamas v Antigua & Barbuda - Friday, 12th October (2300)
Algeria v Benin - Friday, 12th September (2045)
Benin v Algeria - Tuesday, 16th September (1600)
Belarus v Luxembourg - Friday, 12th September (1945)
Luxembourg v San Marino - Monday, 15th September (1945)