The Valiants sit just one point and one place above the Glovers in the bid for EFL survival, making the midweek match a cliched six-pointer.
Claiming their first win in eight outings on Saturday, John Askey’s side will look for back-to-back home wins whilst the green and whites will aim to bounce back from defeat at top of the table Lincoln City.
The 1-0 loss on Friday night stopped Town matching their best winning streak of the campaign of three straight wins.
Looking to start another run, Darren Way will have no fresh injuries to contend with as Gary Warren (hamstring) and Sessi D’Almeida (shoulder) edge closer to a return.
Academy product Gabby Rogers featured for the Under-18s at the weekend as a comeback from an ankle injury to leave a virtually fully-fit squad to choose from.
For Vale, they’ll look for talismanic striker Tom Pope to add to his nine goals so far in 2018/19 with former Glover Ben Whitfield a threat from further back with four goals.
Tuesday night will be the 14th meeting between the two sides with the Glovers looking to even up the record of five wins each.
Meeting four times last season, Town remained unbeaten in all of them by picking up two draws in League Two and a victory in the Emirates FA Cup after a dramatic replay.
Jordan Green’s late header at Vale Park earned a replay in the Second Round, before the Valiants had two sent off to eventually lose 3-2 to strikes from Otis Khan (x2) and Francois Zoko.
Geoff Eltringham will be the man in the middle for midweek action.
Refereeing primarily in the Championship this season, it’ll be his 32nd match of the campaign and first involving the green and whites.
The last Town match he took charge of was in September 2014 when he oversaw at 3-1 win at Bradford City.
On Tuesday he’ll be assisted by James Wilson and Jonathan Hunt with Matthew Donohue acting as fourth official.
A full match report will follow on YTFC.net at full time with post-match reaction from the manager and a member of the playing staff following soon after.