A Steve MacLean double either side of an Anthony Edgar goal wasn't enough for the Glovers as they went down by four goals to three in a thriller at Deepdale this evening.
A Neil Mellor brace plus goals from Barry Nicholson and Jamie Proctor was enough to move the Northenders up to fourth in the League One table in a fantastic advert for third tier football in front of a season's best crowd of 11,474 in Lancashire.
Manager Terry Skiverton opted to stick with the same eleven that started Saturday's goalless draw at Tranmere Rovers with the only changes on the subs bench where Billy Gibson and Abdulai Bell-Baggie dropped out of the squad to be replaced by sub keeper Gareth Stewart and Curtis Haynes-Brown who served his one match ban on the Wirral.
As the game kicked off, the away section of the ground was rapidly filling up with away fans delayed by heavy traffic on the nearby M6 motorway and many fans just got in as the game started.
The late comers may not have seen the game's first chance which saw Luke Ayling's left foot shot gathered safely by home keeper Iain Turner but they certainly saw the game's opening goal on four minutes.
Veteran midfielder Graham Alexander looked to be shaping up for a trademark free kick thirty yards out but he played it short to Neil Mellor who helped it on for Jamie Proctor to turn and hook the ball into the net off the crossbar.
The Glovers were inches away from levelling on nine minutes. Gavin Williams inswinging free kick was met with a looping header from Max Ehmer and the ball, dropping in at the far post, was acrobatically cleared by Alexander.
Williams went off on the quarter hour after being injured in a tackle by the dugouts and was replaced by striker Kieran Agard. The ex-Everton forward was immediately into the action, racing onto a slack back pass from Clarke Carlisle but finding keeper Turner there to block his effort.
On twenty four minutes, Anthony Edgar was caught in two minds as he met Alan O'Brien's deep left wing cross and could only volley straight at Turner in the home goal.
He also tested Turner again a minute later with a left foot shot that the keeper got down to save while at the other end, Jed Steer saved from Iain Hume.
Within sixty seconds, Yeovil had equalised though through Edgar. In a carbon copy of the earlier move, the ex-West Ham star met O'Brien's cross with a much better contact and volleyed into the far corner for 1-1.
The next five minutes became the Neil Mellor show as the former Liverpool frontman spurned three chances to give his side the lead, twice with shots and once with a header from a Paul Parry cross.
Paul Wotton's 35-yard free kick tested Turner's handling late in the first half while Hume turned a Conor McLauhglin cross into the hands of Steer.
Preston started the second period as they began the first, with an early goal to settle the nerves. This time it came from Nicholson who was allowed time and space to shoot past Steer after being set up by Mellor from Parry's cross.
Hume then came more into the game and tried his luck after a solo run through midfield but the next goal came via the impressive Mellor on 58 minutes. Hume headed on to the big striker and he headed home leaving Steer helpless.
Mellor then almost set up number four for Nicholson but his header hit the post and eluded the inracing Nicholson at the far post then the two combined again two minutes later, but this time it was Nicholson whose shot hit the woodwork.
Remarkably, given the pressure on the Yeovil backline, it was the Glovers who then snatched a lifeline on 63 minutes. MacLean hit a hopeful shot from thirty yards that squirmed from Turner's grasp and ended up in the corner of the net.
Preston then looked to have killed the game off with twenty minutes left on the clock. Proctor set up Mellor and his cool finish from twenty yards into the bottom corner made the score 4-2.
Kerrea Gilbert came on for O'Brien on 71 minutes and almost immediately, Mellor nearly grabbed his hat-trick with another shot that rebounded off the post, the third time the Deepdale outfit hit the woodwork.
Dominic Blizzard then came on for his Yeovil debut and within three minutes, yet another goal, this time with a little help from the hosts. Clarke Carlisle handled the ball inside the box and MacLean hit his second, and Yeovil's third with a perfectly driven penalty with nine minutes left.
As the Glovers prepared to throw everything including the kitchen sink in the final ten minutes, it was they who were most likely to hit the eighth goal of the evening. Gilbert got on the end of an Ayling free kick but stabbed his shot wide and then Turner saved from Edgar after MacLean had sprang the offside trap.
Hard luck on Yeovil after an entertaining affair but on possesion and chances alone, the home side deserved their three points and look set to return to the Championship at an early stage.